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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Cryptic self epitopes ： ウィキペディア英語版 Cryptic self epitopes In immunology, cryptic self epitopes are a source of autoimmunity. Self epitopes, which are found in high concentration on the surface of Antigen-presenting cells (APC's) in association with its major histocompatibility complex (MHC) are known as dominant epitopes. These are stimulants of negative selection mechanisms to remove potentially self destructing autoreactive T cells. Their "self" antigens are displayed to a developing T-cell and signal those "self-reactive" T-cells to die via programmed cell death (apoptosis) and thereby deletion from the T cell repertoire, preventing autoimmunity. However, self epitopes which appear in very low concentration on APC are termed cryptic in the sense that they do not delete autoreactive T-cells which will then join the peripheral adult T cell repertoire. This causes autoimmunity in the body. ==References== *http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192044/pdf/je18161945.pdf 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Cryptic self epitopes」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.